The soundtrack was composed by Clint Mansell with the string ensemble performed by Kronos Quartet.
It is notable for its use of sharp string instruments to create a cold and discomforting sound from instruments frequently used for their warmth and softness. The string quartet arrangements were done by Pulitzer Prize-winning composer David Lang. The soundtrack has been widely praised and has subsequently been used in various forms in trailers for other films and series, including The Da Vinci Code, Sunshine, Lost, I Am Legend, Valley of Flowers, Babylon A.D., Zathura, and the video games Assassin's Creedand Lord of the Rings: The Return of the King. More specifically, a version of the recurring theme was reorchestrated for the The Lord of the Rings: The Two Towers film trailer. This version is often known as "Requiem for a Tower." It has also been featured in many other commercials and trailers and as remixes on other artists' albums. For example, G.M.S. are widely known for their mix of the song, titled "Juice by GMS." Lil' Jon's track "Throw It Up" uses a sample from the main theme as the beat. The soundtrack also confirmed its popularity with the remix album Requiem for a Dream: Remixed, which contains new mixes of the music by Paul Oakenfold, Josh Wink, Jagz Kooner, and Delerium, among others. The score is also used as the main theme for the UK's Sky Sports News channel and the entrance theme for the 2007–08 Boston Celtics NBA championship team.
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